Antiviral Significance of Isoquercetin (Quercetin-3-O-Glucoside) With Special Reference to its Anti-Coronaviral Potential

Abstract

Isoquercetin, a naturally occurring dietary flavonoid glycoside, has shown many promising biological activities, such as antioxidant, anti-inflammatory, and anticancer. It also exhibits broad-spectrum antiviral activity, significantly reducing cell infection by influenza, Zika, Ebola, and dengue viruses, among others. Its beneficial effect for mitigating the disease of COVID-19 can be explained due to its inhibitory effects on several stages of the viral life cycle, from entry to replication and virus infectivity, and thus isoquercetin can be a promising anticoronaviral flavonoid to manage severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection and warrants further investigation into its potential use in clinical settings.