Alterations in neurobehavioral and brain neurotransmitters by aloe vera (l.) Burm.f and vitamin E

Abstract

The purpose of the study was to detect the concentrations of noradrenaline (NA), dopamine (DA), serotonin (5-HT)), and their metabolites (3, 4-hydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in mice brain after the long-term administration of Aloe vera (leaf gel) and vitamin E. Control group was treated with 0.9% saline and treated groups were administered Aloe vera leaf gel (500 mg/70kg) and vitamin E (400 IU/70 kg) orally according to the body weight of mice for 30 days daily. After the administration of drug, all groups of animals were killed by decapitation and samples of brain were removed and analyzed after homogenization. Significant changes and alterations in brain biogenic amines can be suggested that the drugs may have potential and use for the treatment of psychotropic diseases and anxiety.