Design, and Synthesis of Aryl Derivatives of Imidazopyridine-Thiadiazoles as Possible Anticancer Agents

Abstract

In this article, we reported a new library of arylthiadiazole analogs of imidazopyridines (9 a–j) designed based on the structures of Nocodazole and Cefozopran. After characterization by spectroscopic data, the synthesized analogs were assessed for anticancer potential using MTT assay against PC3, A549, MCF-7 and DU-145 human cancer cell lines. Etoposide, an anticancer medication candidate, was employed as a positive control. The anticancer activity of the synthesized analogues was expressed in IC50 ranging from 0.01±0.008 μM to 19.3±7.65 μM and compared with positive control. Five compounds 9 d, 9 e, 9 g, 9 h and 9 j possessed more potent anticancer properties.