The treatment of childhood progressive bilateral multiple renal stone disease: A role of essential oil terpenes

Abstract

Background: The association of childhood urolithiasis with idiopathic hypercalciuria plus idiopathic hyperuricosuria has been infrequently reported in children. Treatments of childhood urolithiasis include treatment of the underlying metabolic, and the use of essential oil preparations of terpenic which contains pinene (31%), camphene (15%), borneol (10%), anethol (4%), fenchone (4%) and cineol (3%), which have been used with important benefi ts. Urinex (Pharco Co.) is the essential oil preparations mostly available in the Middle East. The aim of this paper is to emphasize the possible adjunctive role of essential oil preparations of terpenic in the management of serious childhood urolithiasis. Patients and methods: The occurrence of childhood urolithiasis with idiopathic hypercalciuria plus idiopathic hyperuricosuria is reported in a young child and the conservative treatment is described with emphasis on the role of essential oil terpenes in the treatment of urolithiasis. Results: Three years and 4months old girl with urolithiasis associated with idiopathic hypercalciuria plus idiopathic hyperuricosuria presented with recurrent abdominal pain without hematuria, and was treated for about four months with triple therapy consisting of oral hypocalciuric diuretic hydrochlothiazide and amiloride HCl as half tablet of Moduretic (Merck & Co.; hydrochlothiazide 25mg and amiloride 2.5mg) daily, oral allopuriniol 50mg daily, and an essential oil terpene capsule (two capsule twice daily). The effect of treatment on urolithiasis was studied by monthly ultrasound examination which showed signifi cant improvement. Conclusion: This study showed that essential oil terpenes can have important therapeutic benefi ts in the treatment of childhood urolithiasis associated with hypercalciuria plus hyperuricosuria.