Application of the SeDeM Method for Optimization of Tablet Formulations (A Review)

Abstract

A new method of mathematical modeling called Sediment Delivery Model (SeDeM) is reviewed. This method is a convenient tool for determining the suitability of powdered material for direct compression. The method identifies unsatisfactory properties of the material and also determines the type and amount of excipients that should be added to the tablet formulation to neutralize the unsatisfactory properties of the active pharmaceutical ingredient (API). The principles of application of the SeDeM method are considered. The parameters to be determined for application of this method, the equations for calculations, and the constructed diagrams are presented. The methods for application of SeDeM to the pharmaceutical industry and the advantages of such use of the system are described. The SeDeM method is used to optimize and calculate the composition of tablets obtained by direct compression. This system takes into account all the characteristics of the bulk material and provides recommendations for the selection of excipients. The method makes it easier to develop a new drug and simplifies the manufacturing process by eliminating unnecessary excipients. In addition, the method is used for quality control of single APIs and excipients.