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SWI/SNF tumor suppressor gene PBRM1/BAF180 in human clear cell kidney cancer

Molecular and Cellular Oncology
DOI: 10.1080/23723556.2017.1342747
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Abstract

Mutations within chromatin modulating protein complexes have dominated the novel cancer gene landscape. However, little is known about how individual aberrations contribute to cancer formation. A novel Pbrm1 kidney cancer mouse model examining the role of Pbrm1 provides much needed clue concerning how SWI/SNF complexes might function as tumor suppressors.

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Nargund, A. M., Osmanbeyoglu, H. U., Cheng, E. H., & Hsieh, J. J. (2017, July 4). SWI/SNF tumor suppressor gene PBRM1/BAF180 in human clear cell kidney cancer. Molecular and Cellular Oncology. Taylor and Francis Ltd. https://doi.org/10.1080/23723556.2017.1342747

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