Severe critical illness is often complicated by intensive care unit-acquired weakness (ICU-AW), which is associated with increased ICU and post-ICU mortality, delayed weaning from mechanical ventilation and long-term functional disability. Several mechanisms have been implicated in the pathophysiology of ICU-AW, but muscle regeneration has not been investigated to any extent in this context, even though its involvement is suggested by the protracted functional consequences of ICU-AW. Recent data suggest that muscle regeneration could be impaired after sepsis, and that mesenchymal stem cell treatment could improve the post-injury muscle recovery.
CITATION STYLE
Bouglé, A., Rocheteau, P., Sharshar, T., & Chrétien, F. (2016, May 19). Muscle regeneration after sepsis. Critical Care. BioMed Central Ltd. https://doi.org/10.1186/s13054-016-1308-3
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