Antimycobacterial derivatives of tetrazole

Abstract

A synthesis of (1-phenyltetrazol-5-ylthio)acetic acid derivatives has been developed. Functional variations concern the carboxylic group and/or the 4 position of phenyl group. Most of the compounds prepared have been tested with regard to their antimycobacterial activity but the activities found are medium or low ones. However, (1-phenyltetrazol-5-ylthio)acetic acid is better than the antituberculotic isoniazid in the activity to Mycobacterium avium .