The Effect of Giving Ciplukan Herb (Physalis Angulata L) to the Number of Diabetic Nephropathy Glomerulus of Hyperglycemia Rats

Abstract

Hyperglycemia in diabetes mellitus (DM) can damage and impaired function of various organs. The kidney has a very important position in the process of water metabolism in our body. It is often obvious of changes in metabolic substances when the kidney develops a lesion. The organ marked decrease in nephropathy diabetic glomerulus. Oxidative stress at DM results in an imbalance between free radicals and antioxidants. Ciplukan herb (Physalis angulata L.) was an antioxidant that is known to lower blood sugar levels and maintains the function of kidney. The purpose of this study was to determine the effect of Ciplukan (Physalis angulata L) herb to the number of nephropathy diabetic glomerulus of hyperglycemia rats. This study was a true experimental design with a draft of post test design, using one control group and 3 treatment groups. The three treatment groups were the dose variation of ciplukan herb, for 5 mg/kgBW, 10 mg/kg and 20 mg/kgBB in each group-STZ-induced NIC for 21 days. At the end of the study, renal histological preparation was made with hematoxylin and eosin staining (HE). The data were analyzed using ANOVA analysis. The results showed that ciplukan herb extract significantly effect (ρ=0.038) the number of diabetic nephropathy (DN) glomerulus. This implies that ciplukan herb extract improve diabetic nephropathy.