Investigation of Corchorus olitorius mucilage as a potential mucoadhesive agent in developing in situ mucoadhesive nasal gel

Abstract

The present study aimed to formulate a mucoadhesive in situ gel with mucilage extracted from Corchorus olitorius for the intranasal route. Propranolol HCl used as a model drug. For the comparative study, the mucoadhesive in situ gels were prepared using two different concentration 0.4% and 0.5% of C. olitorius mucilage, Carbopol P-934 and hydroxypropyl methylcellulose. The prepared in situ gel was subjected to characterization test, such as pH, appearance, gelation temperature, spreadability, viscosity, mucoadhesive strength, and in vitro study. From the comparative study, 0.5% mucilage containing in situ gel formulation can be considered as optimum formulation.