Long-chain fatty acids and short-chain fatty acids in exhaled breath condensate of patients with chronic obstructive pulmonary disease

Abstract

In present study we performed gas-liquid chromatographic analysis of exhaled breath condensate to measure volatile fatty acids (С2 — acetic, С3 — propionic, С4 — butanoic, isoС4 — isobutyric, C5 — valerianic, C6 — caproic, C7 — heptanoic) and fatty acid with a long aliphatic chain (C14:0 — myristic, C15:0 — pentadecanoic, C16:0 — palmitic, C16:1 — palmitooleic, C17:0 — heptadecanoic, C17:1 — heptadecenoic, C18:0 — stearic, C18:1 — oleic, C18:2 — linolenic, С18:3ω3 — α-linolenic, С20:4ω6 — arachidonic) in patients suffering from moderate chronic obstructive pulmonary disease (2nd stage, GOLD). We revealed the increase of the total amount of short chain fatty acids (С2, С3, С4, С5) and polyunsaturated (С18:2, С20:4ω6) fatty acids, meanwhile the level of saturated fatty acids (С16:0, С17:0, С18:0) decreased.