Mechanism of the Grignard Addition Reaction. X. Kinetics and Deuterium Isotope Effects in the Reaction of Isobutylmagnesium Bromide with Benzophenone.

Abstract

Direct rate measurements and product distribution data were obtained for the reaction of isobutylmagnesium bromide and β-deuterioisobutylmagnesium bromide with benzophenone in Et2O. Interpretation of the results required sepn. of a rate detg. step and a product detg. step if Grignard reagent was in excess, but a one step mechanism was indicated when benzophenone was in excess. [on SciFinder(R)]