Is an IOTA of evidence enough?

Abstract

Clinical question Do patients with acute illness admitted to the hospital and treated with liberal oxygen therapy compared with those treated with conservative oxygen therapy have differences in mortality and morbidity?Article chosen Chu DK, Kim LH, Young PJ, et al. Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta-analysis. Lancet 2018;391(10131):1693-705.Objectives To analyse the existing literature to assess the potential benefits or harms of supplemental oxygen use in acutely ill patients.