The benefits of add-on therapy of vitamin D to the quality of life in diabetic neuropathy patients: a randomized controlled trial

Abstract

Background. Diabetic neuropathy mostly causes physical disabilities that will reduce social participation, medical/psycho-logical rehabilitation, and enjoyable activities. These factors in turn create a cycle of depression, anxiety, and sleep disorders. Variables related to pain perception play an important role, pain catastrophizing will increase anxiety so that sufferers feel they have a disability that is worse than reality. In the end, patients will give up and reduce their self-efficacy. Results. Data from 68 subjects was collected and analyzed. After eight weeks of treatment, the experimental group showed a more significant mood improvement (88.2% vs. 70.6%, p=0.031). There were no adverse events recorded in this study. Conclusions. Vitamin D addition along with standard treatment significantly improve mood more effectively than standard treatment alone in diabetic neuropathy patients.