Phosphorylation of krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomaininteracting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity

Abstract

Background: Krüppel-like factor 3 (KLF3) is a transcriptional repressor with multiple biological roles. Results: Phosphorylation of KLF3 by homeodomain-interacting protein kinase 2 (HIPK2) promotes DNA binding and transcriptional repression. Conclusion: Signal transduction pathways mediated by HIPK2 control and direct KLF3 activity. Significance: Determining the pathways that control KLF3 function offers potential for regulating its activity for therapeutic benefit.