Phramacotherapeutic Evaluation of Parmentiera cereifera Seem. (Family Bignoniaceae) Cultivated in Egypt on Albino Rats

Abstract

See, stats, and : https : //www. researchgate. net/ publication / 276095358 Phramacotherapeutic cereifera . (Family) Cultivated in Article DOI : 10 . 9734 / EJMP / 2015 / 16400 CITATIONS 2 READS 131 4 : Some : Isolation Isolation Nada - Wahab Minia 6 SEE Ashraf Minia 34 SEE Hany Minia 39 SEE Mohamed Minia 146 SEE All . The . ABSTRACT Aims : The current study evaluates different biological activities viz . , anti - inflammatory , anti - hyperglycemic and gastroprotective of methanolic extracts (MEs) of different parts viz . , [ mixture of leaves & stems (1 : 3) (MLS13) , flowers and stem barks ] and different fractions of ME of MLS13 of Parmentiera cereifera Seem . Moreover , this study estimates LD 50 of ME of MLS13 . Place and Duration of Study : The study was carried out for nine months in 2012 in the Methodology : The different MEs of various parts such as MLS13 , flowers and stem barks and the Original Research Article Abdel - Wahab et al . ; EJMP , 8 (1) : 29 - 38 , 2015 ; Article no . EJMP . 2015 . 087 30 different fractions of ME of MLS13 of P . cereifera were used in the present study . The different pharmacological activities such as anti - inflammatory , anti - hyperglycemic , gastroprotective and LD 50 were determined using animal models as described in standard methods . Results : In yeast - induced paw edema method , ME of MLS13 had the highest anti - inflammatory activity (* * * P<0 . 001) . While , in carrageenan - induced paw edema method , the highest anti - inflammatory activity (* * * P<0 . 001) was exhibited by ME of stem barks . Moreover , both ME of flowers (* * * P<0 . 001) and ethyl acetate (EtOAc) fraction (* * * P<0 . 01) exhibited significant anti - hyperglycemic activity in alloxan - induced diabetes method . Furthermore , in indomethacin - induced gastric ulcer method , the highest gastroprotective effect (* * * P<0 . 001) was demonstrated by the petroleum ether (pet . ether) fraction . Finally , there is no toxicity symptoms of ME of MLS13 of P . cereifera up to 5 gm / kg . Conclusion : The biological results revealed that P . cereifera may be used in the development of various pharmaceutical preparations viz . , anti - infalammatory , anti - hypergycemic as well as gastroprotective drugs , due to its wide safety margin .