Mitogenic and Colony-Stimulating Factor-Inducing Activities of Polysaccharide Fractions from the Fruit Bodies of Dictyophora indusiata Fisch

Abstract

Biological effects (mitogenic and colony-stimulating factor (CSF)-inducing activities) of five homogeneous polysaccharides and a conjugated polysaccharide fraction isolated from the fruit bodies of Dictyophora indusiata fisch. were investigated. Fucomannogalactan (T-3-Ad) and conjugated polysaccharide fraction (T-2-A) exhibited significant mitogenic and CSF-inducing activities. Among two /f-(l->6)-branched (l¾3)-/f-D-glucans (T-4-N and T-5-N), only T-4-N showed both mitogenic and CSF-inducing effects. Partially O-acetylated (l-+3)-a-D-mannans (T-2-HN and T-3-M') did not show these effects. © 1991, The Pharmaceutical Society of Japan. All rights reserved.