Improvement of T1 determination of hyperpolarized 129Xe in mouse brain under controlled-flow

Abstract

The method of determining the longitudinal relaxation time of hyperpolarized 129Xe in the mouse brain has been established in vivo with the ventilation technique under controlled-flow conditions. The uptake and washout processes for nine mice were traced through observation of time-dependent changes in NMR (nuclear magnetic resonance) signal amplitudes and analyzed by means of a two-compartment model, thus providing the quantitative value of 14.1±1.6 s as the relaxation time. © 2004 by Japanese Society for Magnetic Resonance in Medicine.