Abstract
Antithrombin-III exerts antiinflammatory effects via ligation of heparan sulfate proteoglycans. Here we show in vitro that recombinant human antithrombin-III attenuates CD11b/CD18 expression of activated neutrophils and monocytes in whole blood ex vivo. As leukocyte integrin expression is triggered by extracorporeal circulation, this observation may be of relevance for pharmacological treatment during cardiopulmonary bypass.
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Gritti, D., Malinverno, A., Gasparetto, C., Wiedermann, C. J., & Ricevuti, G. (2004). Attenuation of leukocyte β2-integrin expression by antithrombin-III. International Journal of Immunopathology and Pharmacology, 17(1), 27–32. https://doi.org/10.1177/039463200401700104
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