Increased plasma levels of nesfatin-1 in patients with newly diagnosed type 2 diabetes mellitus

Abstract

Background: Nesfatin-1, which is derived from nucleobindin2 (NUCB2), has been recently identified as a novel satiety regulator. However, its pathophysiological role in humans remains unknown. The aim of the present study was to investigate plasma nesfatin-1 levels and the association between plasma nesfatin-1 levels and various metabolic parameters in humans. Materials and methods: 74 subjects with newly diagnosed type 2 diabetes mellitus (nT2DM), 73 subjects with impaired glucose tolerance (IGT) and 73 subjects with normal glucose tolerance (NGT) were enrolled in this study. Plasma nesfatin-1 levels were measured by a commercially available enzyme- linked immunosorbent assay. Results: Plasma nesfatin-1 levels were elevated in subjects with both nT2DM and IGT compared to controls (1.910.79 and 1.800.80 vs. 1.410.58g/L, P<0.05 or P<0.01). Simple regression analysis showed that in subjects with IGT and nT2DM, plasma nesfatin-1 correlated positively with body mass index (BMI), hemoglobin A (HbA, fasting blood glucose (FBG), 2h blood glucose after a glucose load (2hPBG), fasting plasma insulin (FINS) and the homeostasis model assessment of insulin resistance (HOMA-. Multivariate logistic regression analysis revealed that plasma nesfatin-1 was significantly associated with IGT and nT2DM, even after controlling for differences in BMI. Conclusion: Plasma nesfatin-1 concentrations were found to be elevated in subjects with both IGT and nT2DM and to be related with several clinical parameters known to be associated with insulin resistance. © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart New York.