Temperature homeostasis in mice lacking the p43 mitochondrial T3 receptor

Abstract

Thyroid hormones and Thra gene play a key role in energy expenditure regulation, temperature homeostasis, and mitochondrial function. To decipher the function of the mitochondrial TRα receptor in these phenomena, we used mice lacking specifically the p43 mitochondrial T3 receptor. We found that these animals were hypermetabolic, hyperphagic, and displayed a down setting of the core body temperature. However, p43-/- animals do not present cold intolerance or defect of facultative thermogenesis. In addition, the mitochondrial function of BAT is slightly affected in the absence of p43. Our study, therefore, suggests a complementarity of action between the mitochondrial receptor and other proteins encoded by the Thra gene in the control of basal metabolism, facultative thermogenesis, and determination of the set point of temperature regulation. p43-/- mice are hypermetabolic and hyperphagic. The absence of p43 leads to a down setting of the core body temperature. p43-/- mice are not cold intolerant. In the absence of p43, Brown Adipose Tissue is functional.