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CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration

National Science Review
DOI: 10.1093/nsr/nwaa033
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Abstract

RNA-targeting CRISPR system Cas13 offers an efficient approach for manipulating RNA transcripts in vitro. In this perspective, we provide a proof-of-concept demonstration that Cas13-mediated Vegfa knockdown in vivo could prevent the development of laser-induced CNV in mouse model of Age-related macular degeneration.

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Zhou, C., Hu, X., Tang, C., Liu, W., Wang, S., Zhou, Y., … Yang, H. (2020, April 17). CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration. National Science Review. Oxford University Press. https://doi.org/10.1093/nsr/nwaa033

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