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Zn2+-Dependent peptide nucleic acid-based artificial ribonucleases with unprecedented efficiency and specificity

Chemical Communications (2021) 57(83) 10911-10914
DOI: 10.1039/d1cc04383h
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Abstract

We present Zn2+-dependent dimethyl-dipyridophenazine PNA conjugates as efficient RNA cleaving artificial enzymes. These PNAzymes display site-specific RNA cleavage with 10 minute half-lives and cleave clinically relevant RNA models.

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Luige, O., Bose, P. P., Stulz, R., Steunenberg, P., Brun, O., Andersson, S., … Strömberg, R. (2021). Zn2+-Dependent peptide nucleic acid-based artificial ribonucleases with unprecedented efficiency and specificity. Chemical Communications, 57(83), 10911–10914. https://doi.org/10.1039/d1cc04383h

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