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Sensing caspase-1 activity using activatable 19F MRI nanoprobes with improved turn-on kinetics

Chemical Communications (2018) 54(83) 11785-11788
DOI: 10.1039/c8cc05381b
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Abstract

Activatable 19F MRI nanoprobes for sensing caspase-1 activity were developed. Tandem repetition of substrate peptide sequences improved the turn-on response of nanoprobes, allowing detection of caspase-1 activity by 19F MRI. In vivo immune response was successfully imaged using the new nanoprobe.

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Akazawa, K., Sugihara, F., Minoshima, M., Mizukami, S., & Kikuchi, K. (2018). Sensing caspase-1 activity using activatable 19F MRI nanoprobes with improved turn-on kinetics. Chemical Communications, 54(83), 11785–11788. https://doi.org/10.1039/c8cc05381b

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