A novel mechanism of latency in matrix metalloproteinases

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Abstract

Background: Animal and plant matrix metalloproteinases (MMPs) are kept zymogenic through large prodomains and a cysteine-switch mechanism.

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López-Pelegrín, M., Ksiazek, M., Karim, A. Y., Guevara, T., Arolas, J. L., Potempa, J., & Gomis-Rüth, F. X. (2015). A novel mechanism of latency in matrix metalloproteinases. Journal of Biological Chemistry, 290(8), 4728–4740. https://doi.org/10.1074/jbc.M114.605956

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