Neuartige biopharmazeutische Wirkstoffe auf der Grundlage von Lipocalinen

Abstract

Anticalins constitute a class of novel binding proteins derived from the human lipocalin scaffold that possess a robust and simple protein architecture providing a set of four hypervariable loops with the ability for tailored molecular recognition similar to antibodies. Applying rational protein engineering in combination with advanced combinatorial library selection techniques, lipocalin variants with specific and tight binding properties for prescribed targets can be generated.