Simultaneous occurrence of multifocal osteomyelitis in a child with acute lymphoblastic leukemia: A rare manifestation during the maintenance phase of treatment

Abstract

Introduction: Acute lymphoblastic leukemia (ALL) has various clinical manifestations due to bone marrow or extra medullary involvement. Osteomyelitismayoccur as the first presentation or relapsing sign of ALL. Multifocal osteomyelitis in non-neutropenic children with ALL is rare. Case Presentation: This study reported on an 8-year-old male with ALL during the maintenance phase of his treatment, who presented fever and generalized body pain. Bone scan showed multiple bones involvement and biopsy was in favor of osteomyelitis. Conclusions: Multifocal osteomyelitis should be kept in mind as a possible diagnosis in patients with leukemia, who are presented with prolonged fever.