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TRIM for Tissue Specificity

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.3c00504
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Abstract

Tissue-specific manipulation of proteins is a long-standing objective in the field of targeted protein degradation, but still a distant prospect. Currently, the most successfully employed E3 ubiquitin ligases belong to the most ubiquitously expressed representatives. Unlocking of the TRIM58 ligase might represent a promising step toward tissue-specific PROTACs and molecular glue degraders.

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Hartmann, M. D. (2024, January 11). TRIM for Tissue Specificity. ACS Medicinal Chemistry Letters. American Chemical Society. https://doi.org/10.1021/acsmedchemlett.3c00504

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