Clinicopathological and survival significance of BAT-25 and BAT-26 instability in breast cancer among Senegalese patients

Abstract

In some tumors, defects in mismatch repair enzymes lead to errors in the replication of simple nucleotide repeat segments. This condition is commonly known as microsatellite instability (MSI) because of the frequent mutations of microsatellite sequences. The primary aim of this study is to evaluate the clinicopathological and survival significance of BAT-25 and BAT-26 instability, in 60 patients with breast cancer. Polymerase chain reaction was used to amplify the following microsatellite repeat loci BAT-25 and BAT-26. Medical records were studied in order to determine clinical data of BAT-25 and BAT-26, analysis was carried out. 60.71% of cancer tissues analyzed were found to be unstable for both markers.BAT-26 instability has an impact on the age (Od: 15.47; CI 1.08-974; 19, P: 0.020) and survival (P: 0.0342) of patients. BAT-26 which has a poly A sequence, can be considered alone as a good marker for the detection of MSI tumors in breast cancer.   Key words: Cancer, breast, polymorphism, microsatellites, Senegal.