Mapping and characterization of the origin of DNA replication of porcine circovirus

  • Mankertz A
  • Persson F
  • Mankertz J
  • et al.
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Abstract

The origin of DNA replication of porcine circovirus (PCV) was mapped to a 111-bp fragment. On top of a hairpin, a nonanucleotide (TAGTATTAC) homologous to nonanucleotides of other viruses was identified. Mutation of this element abolishes replication. PCV may be related to a virus family characterized by single-stranded circular DNA genomes, rolling-circle replication, and homology of their rep proteins.

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Mankertz, A., Persson, F., Mankertz, J., Blaess, G., & Buhk, H. J. (1997). Mapping and characterization of the origin of DNA replication of porcine circovirus. Journal of Virology, 71(3), 2562–2566. https://doi.org/10.1128/jvi.71.3.2562-2566.1997

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