Quick-fat diet inhibits the development of diabetes in spontaneously diabetic torii rats

Abstract

Introduction: The ketogenic diet reportedly improves metabolic disorders, such as obesity and diabetes. The objective of this study was to investigate effects of the Quick-Fat (QF) diet, which contains high-fat and high-sucrose, on the progression of diabetes in SDT rats. Materials and Methods: SDT rats were divided into 2 groups at 5 weeks of age, which were fed a standard diet or the QF diet for 34 weeks. Body weight, calorie intake, and blood glucose and ketone body levels were measured every 2 weeks. The cumulative incidence of diabetes or cataract was also determined. Blood electrolyte levels, such as sodium and potassium, were measured at 25 and 30 weeks of age. Results: The SDT rats fed a QF (QF-SDT) showed an increase of body weight after 7 weeks of age and a decrease of calorie intake after 29 weeks of age. Blood glucose levels in the QF-SDT group decreased after 23 weeks of age, and blood ketone body levels in the QF-SDT group increased after 9 weeks of age. In addition, reduction in the incidence of diabetes or cataract was observed in the QF-SDT group. The changes in blood electrolyte levels were observed in the QF-SDT group at 25 weeks of age, but no changes were observed at 30 weeks of age. Conclusion: SDT rats fed a QF diet showed the delay of diabetic incidence, accompanied by an increase in blood ketone body levels.