Abstract
A series of 1,3-diarylprop-2-en-1-one derivatives 3a-v have been synthesized and evaluated for their ability to inhibit neuraminidase (NA). Among the prepared compounds, the less lipophilic derivative 3k showed the most potent in vitro inhibitory activity against NA with an IC50 value of 1.5 μM.
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Kinger, M., Park, Y. D., Park, J. H., Hur, M. G., Jeong, H. J., Park, S. J., … Yang, S. D. (2012). Design, synthesis, and anti-influenza viral activities of 1,3-diarylprop-2-en-1-ones: A novel class of neuraminidase inhibitors. Archives of Pharmacal Research, 35(4), 633–638. https://doi.org/10.1007/s12272-012-0406-2
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