Flexible cytokine production by macrophages and t cells in response to probiotic bacteria: A possible mechanism by which probiotics exert multifunctional immune regulatory activities

Abstract

Probiotics have been reported to be efficacious against cancers, infections, allergies, inflammatory bowel diseases and autoimmune diseases, and it is important to explain how such multifunctional activities are realized. Lactobacillus casei Shirota (LcS) is one of these multifunctional probiotics, and its ability to augment the host immune system has been extensively examined. We have shown that the cell wall structure of this probiotic strain is responsible for potently inducing IL-12 production. In addition, we have recently found that LcS differentially controls the inflammatory cytokine responses of macrophages and T cells in either Peyer's patches or the spleen. Other studies revealed that LcS-induced IL-12 production by macrophages is modifed when other bacteria or their cell components are simultaneously present. These fndings can provide a theoretical basis for understanding the multifunctional activities of specifc probiotics. © 2011 Landes Bioscience.