24-hour activity cycle behaviors and gray matter volume in mild cognitive impairment

Abstract

INTRODUCTION: The 24-hour activity cycle (24-HAC) includes physical activity (PA), sedentary behavior (SB), and sleep. The 24-HAC composition and brain health relationship in adults with mild cognitive impairment (MCI) remains underexplored. We examined associations between 24-HAC composition and gray matter (GM) volume. METHODS: Cross-sectional study in 110 adults with MCI. Actigraphy assessed 24-HAC behaviors. FreeSurfer quantified GM. Compositional linear regressions and isotemporal substitution determined 24-HAC composition and GM volume associations. RESULTS: Higher moderate-to-vigorous physical activity (MVPA) relative to remaining behaviors was associated with greater right inferior temporal gyrus volume (ß = 0.30, false-discovery rate (FDR)-corrected-p = 0.030). Higher SB relative to remaining behaviors was associated with lower volume in the same region (ß = −0.45, FDR-corrected-p = 0.015). Reallocating 30 min from SB to MVPA predicted 2.1% greater (ß = 0.06, p < 0.001) and from MVPA to SB predicted 2.8% lower volume (ß = −0.08, p < 0.001). DISCUSSION: Increasing MVPA at the expense of SB may protect GM in regions prone to Alzheimer's disease-related atrophy. TRIAL REGISTRATIONS: ClinicalTrials.gov, NCT02926157, NCT02737878, and NCT02669394. Highlights: The 24-hour behaviors are associated to inferior temporal volume in older adults with mild cognitive impairment (MCI). More moderate-to-vigorous physical activity (MVPA) is linked with greater inferior temporal volume in older adults with MCI. Allocation from sedentary time to MVPA predicts greater inferior temporal volume.