How Suppressor Cells Led to Anergy, Costimulation, and Beyond

Abstract

The late 1980s were marked by the end of the suppressor CD8+ T cell era that had reigned for over a decade in the world of immunology. Although the concept of cell-mediated suppression of immune responses reemerged 15 years later as CD4+ regulatory T cells, the CD8+ suppressor T cells, which were