Treatment of graft failure after allogeneic hematopoietic stem cell transplantation: current status

Abstract

Graft failure following hematopoietic stem cell transplantation (HSCT) is an uncommon complication associated with significant morbidity and mortality, prompting the need for further therapy. Although this complication could be overcome by hematopoietic growth factors, augmented immunosuppression, donor leukocyte infusions, and second HSCT with or without preparative conditioning, its treatment success remains limited. More recently, however, several promising approaches have been developing. This report will review the various studies that have attempted to define diagnosis, prognosis and therapy of graft failure. (Journal of Hematopoietic Cell Transplantation 2(3): 61-69, 2013.)