β-secretase inhibitory effects of furanocoumarins from the root of Angelica dahurica

Abstract

In the course of screening antidementia agents from natural products, five β-secretase (BACE1) inhibitors were isolated from the root extract of Angelica dahurica (Umbelliferae). They were identified as furanocoumarins, isoimperatorin (1), imperatorin (2), (+)-oxypeucedanin (3), (+)-byakangelicol (4) and (+)-byakangelicin (5). Among them, compounds 2 and 4 showed significant inhibitory activity against β-secretase (BACE1) with IC50 values of 91.8 ± 7.5 and 104.9 ± 2.4 μM, respectively. Compounds 1-5 inhibited BACE1 activity in a dose-dependent manner. Copyright © 2009 John Wiley & Sons, Ltd.