Solitary intracranial Castleman's disease, plasma cell variant: A case report

Abstract

Objective: We report a case of plasma cell variant of Castleman's disease confined to the meninges. Clinical Presentation and Intervention: A 53-year-old woman presented with severe headache lasting a few months, which was insidious in onset but followed a progressive course with associated vomiting, blurring of vision and diplopia. Investigations revealed a dural-based mass that was considered both radiologically and intraoperatively as a meningioma. Total surgical excision of the mass was performed. Histologically, it was a plasma cell variant of Castleman's disease with κ light chain restriction. Laboratory investigations and whole body computerized tomography scan showed no significant abnormality. A short course of local radiotherapy was given. The patient is well 2 years after treatment. Conclusion: This report highlights the rarity of solitary intracranial Castleman's disease and the difficulty in radiological and intraoperative diagnosis. Copyright © 2007 S. Karger AG.