Biomarkers for Alzheimer's disease in plasma, serum and blood - Conceptual and practical problems

49Citations
Citations of this article
94Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Substances produced throughout the body are detectable in the blood, which is the most common biological fluid used in clinical testing. Biomarkers for Alzheimer's disease (AD) have long been sought in the blood, but none has become an established or validated diagnostic test. Companion reviews in Alzheimer's Research & Therapy will review specific types of biomarkers or applications; in this overview, we cover key concepts related to AD blood biomarker studies in general. Reasons for the difficulty of detecting markers of a brain-specific disorder, such as AD, in the blood are outlined; these pose conceptual challenges for blood biomarker discovery and development. Applications of blood tests in AD go beyond screening and diagnostic testing; other potential uses are risk assessment, prognostication, and evaluation of treatment target engagement, toxicity, and outcome. Opportunities and questions that may surround these different uses are discussed. A systematic approach to biomarker discovery, detection, assay development and quality control, sample collection, handling and storage, and design and analysis of clinical studies needs to be implemented at every step of discovery and translation to identify an interpretable and useful biomarker. © 2013 BioMed Central Ltd.

Cite

CITATION STYLE

APA

Galasko, D., & Golde, T. E. (2013). Biomarkers for Alzheimer’s disease in plasma, serum and blood - Conceptual and practical problems. Alzheimer’s Research and Therapy. https://doi.org/10.1186/alzrt164

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free