Managing the drug treatment of rheumatoid arthritis

Abstract

Rheumatoid arthritis is an inflammatory condition affecting synovial joints. Without treatment, the underlying inflammatory process leads to joint destruction, pain, deformity, disability and accelerated cardiovascular disease. Disease-modifying antirheumatic drugs will attenuate the inflammation. Their benefits are seen at all stages of the disease, however the best outcomes are achieved when they are used shortly after the onset. Patients with suspected rheumatoid arthritis should be referred promptly. Disease-modifying antirheumatic drugs are often used in combination and can have serious adverse effects. Their safe use requires ongoing monitoring to identify potential adverse events. The risk of infection is increased and vaccination is best given before starting disease-modifying antirheumatic drugs.