Predicting the human jejunal permeability and fraction absorbed of fluoroquinolones based on a biophysical model

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Abstract

The purpose of this study is to predict human jejunal permeability (Peff) and fraction absorbed in human (%Fa) for a group of antibacterial fluoroquinolones (FQs), by using a biophysical model based on measured Caco-2 permeability. The predicted Peff (in 10-4 cms-1 units) ranged from 0.7 (norfloxacin) to 4.5 (pefloxacin). The calculated %Fa for norfloxacin = 51% (lit. 35%) and for ciprofloxacin = 76% (lit. 81%). Most of the FQs showed calculated %Fa > 90%, and are expected to be well-absorbed. Estimates of Peff can be predicted by the biophysical model. From these values, the human absorption may be calculated. Where absorption comparisons were possible, the agreement was acceptably good.

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Chenyin, W., Avdeef, A., Wen, Z., & Tam, K. Y. (2014). Predicting the human jejunal permeability and fraction absorbed of fluoroquinolones based on a biophysical model. In Bio-Medical Materials and Engineering (Vol. 24, pp. 3849–3854). IOS Press. https://doi.org/10.3233/BME-141215

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