The purpose of this study is to predict human jejunal permeability (Peff) and fraction absorbed in human (%Fa) for a group of antibacterial fluoroquinolones (FQs), by using a biophysical model based on measured Caco-2 permeability. The predicted Peff (in 10-4 cms-1 units) ranged from 0.7 (norfloxacin) to 4.5 (pefloxacin). The calculated %Fa for norfloxacin = 51% (lit. 35%) and for ciprofloxacin = 76% (lit. 81%). Most of the FQs showed calculated %Fa > 90%, and are expected to be well-absorbed. Estimates of Peff can be predicted by the biophysical model. From these values, the human absorption may be calculated. Where absorption comparisons were possible, the agreement was acceptably good.
CITATION STYLE
Chenyin, W., Avdeef, A., Wen, Z., & Tam, K. Y. (2014). Predicting the human jejunal permeability and fraction absorbed of fluoroquinolones based on a biophysical model. In Bio-Medical Materials and Engineering (Vol. 24, pp. 3849–3854). IOS Press. https://doi.org/10.3233/BME-141215
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