ZnO-NR as the efficient catalyst for the synthesis of new thiazole and cyclopentadienone phosphonate derivatives in water

Abstract

Functionalized thiazoles are generated from the reaction of dimethyl acetylenedicarboxylate, benzoylisothiocyanates, and primary amines and trialkyl phosphite in the presence of ZnO-nanorods as the catalyst in water. Also, a series of polysubstituted cyclopentadienone phosphonate derivatives were synthesized via one-pot multicomponent reactions of primary amines and phosphites with activated acetylenic compounds in water as the solvent at room temperature. Particularly valuable features of this method include high yields of products, broad substrate scope, short reaction time, and straightforward procedure.