Abstract
Appending negatively charged Glu8 tails to a peptide dimer derived from the GCN4 transcription factor leads to an effective suppression of its DNA binding. The specific DNA recognition can be restored by irradiation with UV light by using a photolabile linker between the acidic tail and the DNA binding peptide. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Jiménez-Balsa, A., Pazos, E., Martínez-Albardonedo, B., Mascareñas, J. L., & Vázquez, M. E. (2012). Temporary electrostatic impairment of DNA recognition: Light-driven DNA binding of peptide dimers. Angewandte Chemie - International Edition, 51(35), 8825–8829. https://doi.org/10.1002/anie.201201627
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