The evoked activity of the dorsal root afferent fibres of the spinal cord of white rats in experimental diabetes mellitus

Abstract

We analyzed the functional status of the dorsal root of spinal cord in experimental diabetes mellitus (DM), for instance the parameters of the action potential (AP): threshold, chronaxy and the dynamics of the dorsal root excitability. It was revealed the 1,5 times increase in threshold of excitation when compared to the control animals (P<0,001), the amplitude of AP decreased by 21,7% (P<0,05). It was also revealed a significant increase in response to the 2nd stimulus under applying the paired stimuli on the sciatic nerve in animals with experimental DM. Under applying the stimuli of increasing intensity there was found significant decrease in the amplitude of the AP in animals of the experimental group. It was concluded that hyperglycemia made changes to the processes of excitability and refractoriness in the afferent fibers of the spinal cord.