Influence of white matter fiber orientation on R2* revealed by MRI segmentation

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Abstract

Purpose: To investigate white matter heterogeneity using a multichannel segmentation of a large sample of structural and diffusion magnetic resonance imaging (MRI) data. Materials and Methods: A sample of 50 subjects was segmented using channels comprising exclusively structural (longitudinal and transverse relaxation times T1 and T2 and transverse relaxation rate R2*) and diffusion-based MRI indices (mean diffusivity and fractional anisotropy). These data were analyzed using a data driven approach in which no prior information was used. Results: The analysis revealed the splitting of white matter into two subclasses in which the longitudinal fasciculi were distinguished from inferior/superior ones. The distribution of the adopted indices in the obtained clusters showed that R2* was mainly responsible for this splitting. Conclusion: This result supports the observation, previously hypothesized in the literature, that R2* is influenced by the fiber orientation. J. Magn. Reson. Imaging 2013;37:85-91. © 2012 Wiley Periodicals, Inc. Copyright © 2012 Wiley Periodicals, Inc.

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De Pasquale, F., Cherubini, A., Péran, P., Caltagirone, C., & Sabatini, U. (2013). Influence of white matter fiber orientation on R2* revealed by MRI segmentation. Journal of Magnetic Resonance Imaging, 37(1), 85–91. https://doi.org/10.1002/jmri.23801

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