Stress-induced phosphorylation of Thr486 in c-Myb by p38 mitogen-activated protein kinases attenuates conjugation of SUMO-2/3

Abstract

Background: Regulation of c-Myb transcriptional activity and protein level is essential for hematopoietic homeostasis. Results: p38 MAPKs phosphorylate c-Myb on Thr486, resulting in repression of SUMOylation in stressed cells. Conclusion: There is negative cross-talk between the p38 MAPK phosphorylation pathway and the SUMO-2/3 conjugation pathway that regulates c-Myb activity in stressed cells. Significance: The novel mechanism that modulates activity of c-Myb in stressed cells was identified. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.