Saliva versus peri-implant inflammation: Quantification of il-1β in partially and totally edentulous patients

Abstract

The aim of this study was to investigate the potential use of salivary IL1β in early-stage diagnostics of periimplant inflammation in partially and totally edentulous patients rehabilitated with dental implants. Patients were classified according to peri-implant probing depth and bleeding upon probing in groups of healthy individuals or in groups of individuals with peri-implant inflammation. Data on plaque index, clinical attachment loss, suppuration, and mobility were also assessed. Saliva was collected without stimulation, and the levels of IL- 1β were determined by ELISA. Healthy groups demonstrated significantly lower levels of IL-1β compared with the inflammation groups. No difference in IL-1β levels was observed between partially edentulous or totally edentulous patients. Salivary IL-1β may be useful for the diagnosis and monitoring of early peri-implant inflammation, particularly in edentulous patients. © 2014 American Academy of Implant Dentistry.