Unraveling the Potential of Cyclic N-Sulfonyl Ketimines in the MCR Universe

Abstract

Cyclic N-sulfonyl ketimines constitute an accessible class of lead-like heterocycles with a vast application in both synthetic organic and medicinal chemistry. In this context, we harness the capabilities of these heterocycles in four different isocyanide-based multicomponent reactions. Our goal was to create libraries of compounds with functional groups and vectors that are compatible for structural elaboration and optimization of their physical properties. We synthesized 15 unprecedented compounds with high diversity and complexity, whereas we have obtained four single crystal structures of each scaffold, unraveling their geometrical features and potential employment in drug discovery.