Analysis of the prognostic factor in the patients with locally invasive bladder cancer who underwent total cystectomy

Abstract

(Objectives) Prognosis and related factors were analysed as for the patients with locally invasive bladder cancer who underwent total cystectomy and pelvic lymphnode dissection. (Methods) Between January 1977 and December 1996, a hundred and one patients with locally invasive bladder cancer underwent total cystectomy and pelvic lymphnode dissection at University Hospital. Survival rates of these patients were calculated by Kaplan-Meier method and statistical significances were analysed by univariate and multivariate analyses. (Results) Most significant factor was PS at cystectomy and pN was next. Survival rate of the patients who underwent total cystectomy after 1988 showed significantly better than others. Thirteen patients achieved complete response by preoperative therapy. But, two of them who had positive nodes were died by cancer. (Conclusion) Considering from these results, performance status at cystectomy and lymphnode metastasis are predictable prognostic factor for locally invasive bladder cancer patients.