Relationship between sleep duration, physical activity, and hyperuricemia: a cross-sectional study of college freshmen

Abstract

Background: The increasing prevalence of hyperuricemia (HUA) leads to a high disease burden and has become an important public health problem. However, relevant epidemiological studies of associations between HUA and lifestyle factors among young Chinese adults are limited. This study aims to evaluate the correlation between sleep duration and physical activity (PA), and HUA among young adults in China. Methods: A total of 3362 freshmen from a medical college were included in this cross-sectional study. Sleep duration and PA were assessed through electronic questionnaires. HUA was defined as serum uric acid concentrations ≥ 420 umol/L (7.0 mg/dL) for males and ≥ 360 umol/L (6.0 mg/dL) for females. The logistic regression, generalized linear model and restricted cubic splines were used to evaluate these associations. Results: The average age of students was about 18.45 years and the prevalence of HUA was 32.06%. Students who slept less than 8 h per night had a higher risk of HUA compared to those who slept 8–9 h [OR (95%CI):1.200 (1.023, 1.408)]. These associations were particularly pronounced among female students with [OR (95%CI):1.269 (1.034, 1.557)]. Compared with light PA, students who participated in moderate and vigorous PA were associated with a lower risk of HUA with [OR (95%CI): 0.749 (0.637, 0.882)] and [OR (95%CI): 0.755 (0.587, 0.972)]. However, no significant multiplicative interaction was observed between sleep duration and PA with HUA. Conclusions: Sleep duration and PA were associated with HUA in young adults, adequate sleep duration and PA might be associated with a lower risk of HUA.